Risperidone and Divalproex Differentially Engage the Fronto- Striato-Temporal Circuitry in Pediatric Mania: A Pharmacological fMRI Study
نویسندگان
چکیده
Mani N. Pavuluri, MD PhD, Alessandra M. Passarotti, PhD, Jacklynn M. Fitzgerald, BA, Ezra Wegbreit, PhD, and John A. Sweeney, Ph.D. Drs. Pavuluri, Passarotti, Wegbreit, and Ms. Fitzgerald are with the Pediatric Brain Research and Intervention Center, Institute for Juvenile Research, Berger-Colbeth Clinic, University of Illinois at Chicago. Dr. Sweeney is with the University of Texas South Western.
منابع مشابه
Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania.
OBJECTIVE The aim of the current study was to determine the influence of implicated affective circuitry disturbance in pediatric bipolar disorder (PBD) on behavioral inhibition. The differential influence of an antipsychotic and an anti-epileptic medication on the functional connectivity across affective and cognitive neural operations in PBD was examined. METHODS This was a six-week double b...
متن کاملDouble-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder.
OBJECTIVE To determine the relative effects of risperidone and divalproex in pediatric mania. METHODS This is a double-blind, randomized, outpatient clinical trial with 66 children and adolescents (mean age= 10.9 ± 3.3 years; age range= 8-18 years) with mania who were randomly assigned to either risperidone (0.5-2 mg/day, n= 33) or divalproex (60-120 μg/mL, n= 33) for a six-week period. Measu...
متن کاملMission statement: advancing the science of pediatric mental health and promoting the care of youth and their families.
EDITORIALS 566 Translations and Perspectives: Toward a More Perfect Union 568 Ethics and Research With Vulnerable Children 571 Rage Takes Center Stage NEW RESEARCH 574 Mental Health Problems in Young Children Investigated by U.S. Child Welfare Agencies 584 Rage Attacks in Pediatric OCD 595 Multidimensional Approach to Preschool Disruptive Behavior 607 Bipolar Disorder and Research Interviews 62...
متن کاملDouble-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes
Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes Mani N. Pavuluri*, Alessandra M. Passarotti, Lisa H. Lu, Julie A. Carbray, John A. Sweeney a Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL USA; b Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at ...
متن کاملA fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics.
A key feature of schizophrenia is the inability to screen out irrelevant sensory input. Prepulse inhibition (PPI) of the startle response, a cross-species measure of sensorimotor gating, provides a valuable opportunity to study this feature. PPI is reliably impaired in schizophrenia. Animal models of disrupted PPI have proved valuable for the evaluation of antipsychotic substances. The cortico-...
متن کامل